Epic Numbers on Anti-Depressants Today: Withdrawal Advice

December 17, 2025

Long-term prescription rates for antidepressants in the UnitedStates and Britain have doubled over the past decade, with similar trends inother Western countries.

More than 15 million Americans have taken the medications for atleast five years, a rate that has almost more than tripled since 2000,according to a New York Times analysis of federal data.

The field of psychiatry has conducted few rigorous studies ofantidepressant withdrawal (despite mounting interest).

Dr. Mark Horowitz, a clinical research fellow at Britain’sNational Health Service and King’s College London, and Dr. David Taylor, a professor ofpsychopharmacology at King’s College and a member of the South London andMaudsley N.H.S. Foundation Trust, decided to address the topic in part becauseof their own experiences with medication.

Dr. Horowitz said he had severe withdrawalsymptoms after tapering down after 15 years on antidepressants. Dr. Taylor hadpreviously written about his own struggles tryingto taper off.

Dutch researchers in 2018 found that 70 percent ofpeople who’d had trouble giving up Paxil orEffexor quit their prescriptions safely by following an extended taperingregimen, reducing their dosage by smaller and smaller increments, down toone-fortieth of the original amount.


This is the regimen recommended in the new paper published Tuesday [March 5, 2019] in the Lancet.   Co-authors Horowitz and Taylor, both psychiatrists, argue that any responsible withdrawal regimen should have the patient tapering off medication over months or even years, depending on the individual, and not over four weeks, the boilerplate advice.

Laura Delano, executive director of Inner Compass Initiative, a nonprofit organization that runs The Withdrawal Project and focuses on helping people learn about safer psychiatric drug tapering, said: “I didn’t know about the benefits of slow tapering when I came off five meds in five months, and had a very difficult time in withdrawal.”

The new paper, she added, “speaks to how hardit is to get this information into the clinical world. We laypeople have beensaying this for a long time, and it’s telling that it took psychiatrists comingoff meds themselves for this information to finally be heard.”

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Above was extracted from an article in the New York Times: https://www.nytimes.com/2019/03/05/health/depression-withdrawal-drugs.html

If you are interested in exploring effective alternatives toantidepressants, check out presentations on https://imhu.org/shop.  The short course on Nutrition, Micronutrients and MentalHealth offered by psychiatrist, Pam Shervanick, would be of particularvalue.